I've just created a twitter app on Windows Azure that allows you to get a list of people who you are following but are not following you. I call this, finding out who your true friends are. :) But it should also be helpful to control your Twitter ratio so that you don't look like another marketer or spammer.
The app is up at http://ruf.cloudapp.net.
I have not tested it with a large follower base but it should work fine.... hopefully. Let me know if it fails for you.
This app was created one afternoon but it took almost a day to test and load it up properly to the cloud. Until then, the application is probably going to improved as the need arises. Let me know what you think.